Comprehensive Metabolic Panel
CPT 80053
Status X Statutory exclusion. The service is not in the statutory definition of physician services. Full definition →No national payment amount
Status X is not separately payable under the PFS.
Statutory exclusion. The service is not in the statutory definition of physician services.
Common questions
Why is there no payment amount for 80053?
Its status indicator is X (statutory exclusion). Statutory exclusion. The service is not in the statutory definition of physician services. The blank is deliberate: the amount is unknown or paid another way, not zero.
When does this rate change?
CMS publishes a fee schedule release every quarter (January, April, July, October). Each release is versioned here, so past quarters stay lookupable — see what changed each release, or get an email when a new release moves rates.
Sources: CMS Medicare Physician Fee Schedule Relative Value Files.
Saw this code on your bill?
What is a 80053 visit in patient-friendly terms?
In plain terms: A broader blood chemistry panel that adds liver enzymes and protein measures to the basic metabolic panel. It is one of the most commonly ordered screening panels. You'll typically see CPT 80053 on a bill or explanation of benefits (EOB) when a clinician performs or bills for this service.
How this amount is computed
amount = (work RVU × work GPCI + PE RVU × PE GPCI + MP RVU × MP GPCI) × conversion factor. National amounts use GPCI = 1.000.
| Component | RVU |
|---|---|
| Work RVU | blank |
| Practice expense RVU (non-facility) | blank |
| Practice expense RVU (facility) | blank |
| Malpractice RVU | blank |
Every rate combines three parts: work (the clinician’s time, skill and effort), practice expense (office overhead — higher when the service is done in a doctor’s own office), and malpractice (the share of liability-insurance cost). A value of blank means CMS publishes no national number for that part — which is not the same as zero.
Rate history by release
National non-facility amount for 80053 across quarterly releases.
Billing together (NCCI edits)
NCCI Q3 2026Per CMS's National Correct Coding Initiative. Hover a code for when it's used.
Never billable with 80053 on the same date of service
Billable with 80053 only with modifier 59, XE, XS, XP, or XU